An ingredient found in red wine can combat the harmful effects of obesity and reduce the risk of disease in the elderly, a clinical trial has shown for the first time.
The compound is found in red wine and grapes
When taken regularly a natural compound known as resveratrol, found in red
wine and grapes, mulberries and peanuts, can offer similar benefits to
low-calorie diets and endurance training. As well as lowering the metabolism – meaning the body needs less food to
generate enough energy – it can reduce levels of liver fat, blood pressure
and blood sugar.
The compound also improves the rate at which the muscles burn fat, lessens
insulin resistance and could protect against certain age-related diseases
like Type 2 diabetes and cancer, experts said.
Unfortunately, to consume the amount of resveratrol given to patients in the
study a wine-drinker would need to work their way through more than 13
bottles a night, doing far more harm than good.
But researchers said the 150mg dose could easily be taken as a daily capsule
with water, or incorporated into existing food supplements.
Prof Patrick Schrauwen of Maastricht University in The Netherlands, who led
the study, said the benefits of resveratrol for obese people were small but
significant.
He said: "I think the positive thing is that they were very consistent, they cause a small difference on a lot of different parameters.
"Also, we only gave it to patients for 30 days and we do not know what would happen if we gave it for longer. Metabolic changes can take a while before they start to appear so it is quite possible the effects could be larger."
Dr Andrew Murray, of Cambridge University, who was not involved in the study, said it provided the first real evidence that resveratrol could have a significant effect in humans.
He said: "Although the effects are slight they could make all the difference to people with metabolic complications like obesity.
"What is very exciting about this is that there are many problems related to obesity and the onset of diabetes, and what this study seems to show is that it is not going to make people thin again but it could slow down all the problems associated with lifelong obesity."
The researchers gave daily injections of resveratrol to 11 obese male patients for a month and found it altered their metabolism in a similar, although weaker, way than extreme dieting or endurance training.
The treatment lowered systolic blood pressure by 5mmHg and reduced the amount of energy participants used by two to four per cent, indicating that their metabolism had slowed down.
Biologically speaking this is healthy because it means we require less energy and need to eat less, but the researchers admitted that burning fewer calories may not be desirable for obese patients.
Prof Schrauwen said: "In our society with so much obesity people want to have a high metabolism because it is easier to lose weight.
"But the lowering of your energy metabolism is actually a good thing because it means that you become more efficient."
Because the eleven patients tested in the study, published in the Cell Metabolism journal, were all obese men it is not clear whether slimmer people would benefit in the same way.
Prof Schrauwen said: "I can imagine it will work better in people who already have some disturbances in their metabolism – if your blood pressure and blood glucose are normal, then it might not be lowered."
He said: "I think the positive thing is that they were very consistent, they cause a small difference on a lot of different parameters.
"Also, we only gave it to patients for 30 days and we do not know what would happen if we gave it for longer. Metabolic changes can take a while before they start to appear so it is quite possible the effects could be larger."
Dr Andrew Murray, of Cambridge University, who was not involved in the study, said it provided the first real evidence that resveratrol could have a significant effect in humans.
He said: "Although the effects are slight they could make all the difference to people with metabolic complications like obesity.
"What is very exciting about this is that there are many problems related to obesity and the onset of diabetes, and what this study seems to show is that it is not going to make people thin again but it could slow down all the problems associated with lifelong obesity."
The researchers gave daily injections of resveratrol to 11 obese male patients for a month and found it altered their metabolism in a similar, although weaker, way than extreme dieting or endurance training.
The treatment lowered systolic blood pressure by 5mmHg and reduced the amount of energy participants used by two to four per cent, indicating that their metabolism had slowed down.
Biologically speaking this is healthy because it means we require less energy and need to eat less, but the researchers admitted that burning fewer calories may not be desirable for obese patients.
Prof Schrauwen said: "In our society with so much obesity people want to have a high metabolism because it is easier to lose weight.
"But the lowering of your energy metabolism is actually a good thing because it means that you become more efficient."
Because the eleven patients tested in the study, published in the Cell Metabolism journal, were all obese men it is not clear whether slimmer people would benefit in the same way.
Prof Schrauwen said: "I can imagine it will work better in people who already have some disturbances in their metabolism – if your blood pressure and blood glucose are normal, then it might not be lowered."
